Celecoxib decreases effects of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Check. Helps prevent conversion of codeine to its Energetic metabolite morphine. chlorpromazine will minimize the extent or result of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Helps prevent conversion of codeine to its Lively metabolite morphine https://wockusa.com/product-category/anti-cancer/