DNA ligases seal 5′-PO4 and 3′-OH polynucleotide finishes by way of a few nucleotidyl transfer methods involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are crucial guardians of genomic integrity, and ligase dysfunction underlies human genetic sickness syndromes. Crystal structures of DNA ligases certain to nucleotide and nucleic acid substrates https://hankj788qje3.blue-blogs.com/profile